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1

Targeting brain aminopeptidase A, a new strategy for the treatment of hypertension and heart failure

Marc, Yannick, Boitard, SolÃ¨ne Emmanuelle, Balavoine, Fabrice, Azizi, Michel, Llorens-Cortes, Catherine

Journal:

Canadian Journal of Cardiology

Year:

2020

File:

PDF, 2.08 MB

2020

2

Apelin and its receptor in corticotrophs: Localization and physiological relevance

A. Reaux-Le Goazigo, R. Alvear-Perez, P. Zizzari, J. Epelbaum, M.-T. Bluet-Pajot, C. Llorens-Cortes

Journal:

Frontiers in Neuroendocrinology

Year:

2006

Language:

english

File:

PDF, 39 KB

english, 2006

3

Angiotensin III: a central regulator of vasopressin release and blood pressure

Annabelle Reaux, Marie Claude Fournie-Zaluski, Catherine Llorens-Cortes

Journal:

Trends in Endocrinology & Metabolism

Year:

2001

Language:

english

File:

PDF, 78 KB

english, 2001

4

Study of Asparagine 353 in Aminopeptidase A: Characterization of a Novel Motif (GXMEN) Implicated in Exopeptidase Specificity of Monozinc Aminopeptidases

Iturrioz, Xavier, Rozenfeld, Raphaël, Michaud, Annie, Corvol, Pierre, Llorens-Cortes, Catherine

Journal:

Year:

2001

Language:

english

File:

PDF, 269 KB

english, 2001

5

Central Apelin Controls Glucose Homeostasis via a Nitric Oxide-Dependent Pathway in Mice

Duparc, Thibaut, Colom, André, Cani, Patrice D., Massaly, Nicolas, Rastrelli, Sophie, Drougard, Anne, Le Gonidec, Sophie, Moulédous, Lionel, Frances, Bernard, Leclercq, Isabelle, Llorens-Cortes, Cathe

Journal:

Antioxidants & Redox Signaling

Year:

2011

Language:

english

File:

PDF, 1.59 MB

english, 2011

6

Brain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: A potential treatment of salt-dependent hypertension

Fournie-Zaluski, M.-C., Fassot, C., Valentin, B., Djordjijevic, D., Reaux-Le Goazigo, A., Corvol, P., Roques, B. P., Llorens-Cortes, C.

Journal:

Proceedings of the National Academy of Sciences

Year:

2004

Language:

english

File:

PDF, 387 KB

english, 2004

7

Inhibiteurs de l’aminopeptidase A comme nouveau traitement potentiel de l’hypertension artérielle

Hmazzou, R., Llorens-Cortes, C.

Journal:

Archives des Maladies du Coeur et des Vaisseaux - Pratique

Year:

2017

Language:

french

File:

PDF, 518 KB

french, 2017

8

NI956/QGC006, a Potent Orally Active, Brain-Penetrating Aminopeptidase A Inhibitor for Treating Hypertension

Keck, Mathilde, De Almeida, Hugo, Compère, Delphine, Inguimbert, Nicolas, Flahault, Adrien, Balavoine, Fabrice, Roques, Bernard, Llorens-Cortes, Catherine

Journal:

Year:

2019

File:

PDF, 514 KB

2019

9

Orally Active Aminopeptidase A Inhibitor Prodrugs: Current State and Future Directions

Keck, Mathilde, Hmazzou, Reda, Llorens-Cortes, Catherine

Journal:

Current Hypertension Reports

Year:

2019

File:

PDF, 1.01 MB

2019

10

A pilot double-blind randomized placebo-controlled crossover pharmacodynamic study of the centrally active aminopeptidase A inhibitor, firibastat, in hypertension

Azizi, Michel, Courand, Pierre-Yves, Denolle, Thierry, Delsart, Pascal, Zhygalina, Valentina, Amar, Laurence, Lantelme, Pierre, Mounier-Vehier, Claire, De Mota, Nadia, Balavoine, Fabrice, Llorens-Cort

Journal:

Journal of Hypertension

Year:

2019

File:

PDF, 608 KB

2019

11

Evolution of a New Class of Antihypertensive Drugs

Llorens-Cortes, Catherine, Touyz, Rhian M.

Journal:

Year:

2020

File:

PDF, 946 KB

2020

12

P4554Central-acting aminopeptidase a inhibitors for new treatment of hypertension: from discovery to clinical trial

Llorens-Cortes, C, Marc, Y, Hmazzou, R, Keck, M, Flahault, A, Roques, B P, Balavoine, F, Azizi, M

Journal:

European Heart Journal

Year:

2019

File:

PDF, 480 KB

2019

13

Distribution of angiotensin II type-2 receptor (AT2) mRNA expression in the adult rat brain

Lenkei, Zsolt, Palkovits, Miklos, Corvol, Pierre, Llorens-Cortes, Catherine

Journal:

The Journal of Comparative Neurology

Year:

1996

Language:

english

File:

PDF, 2.16 MB

english, 1996

14

Ontogeny of angiotensin II type 2 receptor mRNA expression in fetal and neonatal rat brain

Anne Monique Nuyt, Zsolt Lenkei, Miklos Palkovits, Pierre Corvol, Catherine Llorens-Cortés

Journal:

The Journal of Comparative Neurology

Year:

1999

Language:

english

File:

PDF, 986 KB

english, 1999

15

Ontogeny of angiotensin II type 1 receptor mRNAs in fetal and neonatal rat brain

Anne Monique Nuyt, Zsolt Lenkei, Pierre Corvol, Miklós Palkovits, Catherine Llorens-Cortés

Journal:

The Journal of Comparative Neurology

Year:

2001

Language:

english

File:

PDF, 832 KB

english, 2001

16

Cell adhesion markers are expressed by a stable human endothelial cell line transformed by the SV40 large T antigen under vimentin promoter control

Patrick Vicart, Patrice Testut, Bertrand Schwartz, Catherine Llorens-Cortes, Juana J. Perdomo, Denise Paulin

Journal:

Journal of Cellular Physiology

Year:

1993

Language:

english

File:

PDF, 1.36 MB

english, 1993

17

Synthesis and separation of tritiated inhibitors of aminopeptidase A and their prodrugs

Nicolas Inguimbert, Pascale Coric, Hélène Dhotel, Catherine Llorens-Cortes, Marie-Claude Fournié-Zaluski, Bernard P. Roques

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

2004

Language:

english

File:

PDF, 186 KB

english, 2004

18

Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain

Annabelle Reaux, Nadia De Mota, Ivana Skultetyova, Zsolt Lenkei, Said El Messari, Katalin Gallatz, Pierre Corvol, Miklos Palkovits, Catherine Llorens-Cortès

Journal:

Journal of Neurochemistry

Year:

2001

Language:

english

File:

PDF, 665 KB

english, 2001

19

Aminopeptidase A activity and angiotensin III effects on [Ca2+]i along the rat nephron

Hus-Citharel, Annette, Gasc, Jean-Marie, Zini, Sylvie, Marchetti, Jeannine, Roques, Bernard, Corvol, Pierre, Llorens-Cortes, Catherine

Journal:

Kidney International

Year:

1999

Language:

english

File:

PDF, 799 KB

english, 1999

20

Potentiation of [Ca2+]i response to angiotensin III by cAMP in cortical thick ascending limb

Hus-Citharel, Annette, Marchetti, Jeannine, Corvol, Pierre, Llorens-Cortes, Catherine

Journal:

Kidney International

Year:

2002

Language:

english

File:

PDF, 439 KB

english, 2002

21

Neuronal and non-neuronal histamine in rat brain: tentative localization of the nerve cell bodies

G. Barbin, M. Garbarg, C. Llorens-Cortes, H. Pollard, J. -C. Schwartz

Journal:

Inflammation Research

Year:

1977

Language:

english

File:

PDF, 143 KB

english, 1977

22

Topographical distribution of histamine and histidine decarboxylase activity in hypothalamus and brain stem modifications by lesions

H. Pollard, G. Barbin, S. Bischoff, M. Garbarg, C. Llorens-Cortes, J. -C. Schwartz

Journal:

Inflammation Research

Year:

1977

Language:

english

File:

PDF, 78 KB

english, 1977

23

Characterization and inhibition of aminopeptidase A by α-mercapto-β-amino acyl dipeptides

Christelle David, Laurent Bischoff, Hervé Meudal, Catherine Llorens-Cortes, Bernard Pierre Roques, Marie-Claude Fournié-Zaluski

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1997

Language:

english

File:

PDF, 229 KB

english, 1997

24

Aminopeptidase A inhibitors as centrally acting antihypertensive agents

Laurence Bodineau, Alain Frugière, Yannick Marc, Cédric Claperon, Catherine Llorens-Cortes

Journal:

Heart Failure Reviews

Year:

2008

Language:

english

File:

PDF, 429 KB

english, 2008

25

Role of angiotensin III in hypertension

Annabelle Reaux-Le Goazigo, Xavier Iturrioz, Celine Fassot, Cedric Claperon, Bernard P. Roques, Catherine Llorens-Cortes

Journal:

Current Hypertension Reports

Year:

2005

Language:

english

File:

PDF, 987 KB

english, 2005

26

6-Hydroxydopamine Lesions of the Locus Coeruleus Induce a Paradoxical Increase in Growth Hormone Secretion in Male Rats

M. T. Bluet-Pajot, F. Mounier, D. Durand, C. Kordon, C. Llorens-Cortes, C. Videau, J. Epelbaum

Journal:

Journal of Neuroendocrinology

Year:

1992

Language:

english

File:

PDF, 569 KB

english, 1992

27

Jacques Benoit Lecture: The Neuroendocrine View of the Angiotensin and Apelin Systems

C. Llorens-Cortes, C. Kordon

Journal:

Journal of Neuroendocrinology

Year:

2008

Language:

english

File:

PDF, 242 KB

english, 2008

28

Synthesis and in vitro activities of new non-peptidic APA Inhibitors

N. Inguimbert, P. Coric, H. Dhotel, E. Bonnard, C. Llorens-Cortes, N. De Mota, M.-C. Fournié-Zaluski, B.-P. Roques

Journal:

Chemical Biology & Drug Design

Year:

2005

Language:

english

File:

PDF, 377 KB

english, 2005

29

Ghrelin and obestatin modulate growth hormone-releasing hormone release and synaptic inputs onto growth hormone-releasing hormone neurons

Dan D. Feng, Seung-Kwon Yang, Catherine Loudes, Axelle Simon, Tamara Al-Sarraf, Michael Culler, Rodrigo Alvear-Perez, Catherine Llorens-Cortes, Chen Chen, Jacques Epelbaum, Robert Gardette

Journal:

European Journal of Neuroscience

Year:

2011

Language:

english

File:

PDF, 1.11 MB

english, 2011

30

RADIOIMMUNOASSAY OF METHIONINE-AND LEUCINE-ENKEPHALINS IN REGIONS OF RAT BRAIN AND COMPARISON WITH ENDORPHINS ESTIMATED BY A RADIORECEPTOR ASSAY

C. Gros, P. Pradelles, C. Rouget, O. Bepoldin, F. Dray, M. C. Fournie-Zaluski, B. P. Roques, H. Pollard, C. Llorens-Cortes, J. C. Schwartz

Journal:

Journal of Neurochemistry

Year:

1978

Language:

english

File:

PDF, 720 KB

english, 1978

31

Enkephalinergic Markers in Substantia Nigra and Caudate Nucleus from Parkinsonian Subjects

C. Llorens-Cortes, F. Javoy-Agid, Y. Agid, H. Taquet, J. C. Schwartz

Journal:

Journal of Neurochemistry

Year:

1984

Language:

english

File:

PDF, 370 KB

english, 1984

32

A Novel Potential Metallopeptidase Derived from the Enkephalinase Gene by Alternative Splicing

Catherine Llorens-Cortes, Bruno Giros, Jean-Charles Schwartz

Journal:

Journal of Neurochemistry

Year:

1990

Language:

english

File:

PDF, 351 KB

english, 1990

33

Dopaminergic Regulation of Enkephalin Release

C. Llorens-Cortes, S. Zini, C. Gros, J.-C. Schwartz

Journal:

Journal of Neurochemistry

Year:

1991

Language:

english

File:

PDF, 833 KB

english, 1991

34

Functional dissociation of apelin receptor signaling and endocytosis: implications for the effects of apelin on arterial blood pressure

Said El Messari, Xavier Iturrioz, Celine Fassot, Nadia De Mota, Darren Roesch, Catherine Llorens-Cortes

Journal:

Journal of Neurochemistry

Year:

2004

Language:

english

File:

PDF, 279 KB

english, 2004

35

Human brain aminopeptidase A: biochemical properties and distribution in brain nuclei

Nadia De Mota, Xavier Iturrioz, Cedric Claperon, Laurence Bodineau, Celine Fassot, Bernard Pierre Roques, Miklos Palkovits, Catherine Llorens-Cortes

Journal:

Journal of Neurochemistry

Year:

2008

Language:

english

File:

PDF, 698 KB

english, 2008

36

METABOLIC PATHWAYS AND RESPECTIVE ROLES OF BRAIN ANGIOTENSIN II AND III IN VASOPRESSIN RELEASE

S. Zini, M-C. Fournié-Zaluski, E. Chauvel, B.P. Roques, P. Corvol, C. Llorens-Cortes

Journal:

Fundamental & Clinical Pharmacology

Year:

1997

Language:

english

File:

PDF, 80 KB

english, 1997

37

Enkephalin receptors on dopaminergic neurones in rat striatum

POLLARD, H., LLORENS-CORTES, C., SCHWARTZ, J. C.

Journal:

Year:

1977

File:

PDF, 365 KB

1977

38

Ontogeny of angiotensin II type 2 (AT2) receptor mRNA in the rat

Shanmugam, Sadoutounissa, Lenkei, Zsolt G, Gasc, Jean-Marie R, Corvol, Pierre L, Llorens-Cortes, Catherine M

Journal:

Kidney International

Year:

1995

Language:

english

File:

PDF, 719 KB

english, 1995

39

Characterization and inhibition of aminopeptidase A by α-mercapto-β-amino acyl dipeptides

Christelle David, Laurent Bischoff, Hervé Meudal, Catherine Llorens-Cortes, Bernard Pierre Roques, Marie-Claude Fournié-Zaluski

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1997

Language:

english

File:

PDF, 94 KB

english, 1997

40

Expression of Angiotensin Type-1 (AT1) and Type-2 (AT2) Receptor mRNAs in the Adult Rat Brain: A Functional Neuroanatomical Review

Z. Lenkei, M. Palkovits, P. Corvol, C. Llorens-Cortès

Journal:

Frontiers in Neuroendocrinology

Year:

1997

Language:

english

File:

PDF, 2.32 MB

english, 1997

41

Roles of brain angiotensins II and III in thirst and sodium appetite

Wendy L. Wilson, Bernard P. Roques, Catherine Llorens-Cortes, Robert C. Speth, Joseph W. Harding, John W. Wright

Journal:

Year:

2005

Language:

english

File:

PDF, 432 KB

english, 2005

42

The RFamide neuropeptide 26RFa and its role in the control of neuroendocrine functions

Nicolas Chartrel, Jessy Alonzeau, David Alexandre, Lydie Jeandel, Rodrigo Alvear-Perez, Jérôme Leprince, Jean Boutin, Hubert Vaudry, Youssef Anouar, Catherine Llorens-Cortes

Journal:

Frontiers in Neuroendocrinology

Year:

2011

Language:

english

File:

PDF, 509 KB

english, 2011

43

Effects of angiotensin II and antagonists on AT1 receptor expression in mesangial cells

Dominique Chansel, Sophie Vandermeersch, Catherine Llorens-Cortes, Raymond Ardaillou

Journal:

European Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 688 KB

english, 1999

44

Production and properties of a recombinant soluble form of aminopeptidase A

Gilles Vazeux, Sherwin Wilk, Elizabeth Wilk, Pierre Corvol, Catherine Llorens-Cortès

Journal:

Year:

1998

Language:

english

File:

PDF, 460 KB

english, 1998

45

Apelin and Vasopressin: Two Work Better than One

Catherine Llorens-Cortes, Francoise Moos

Journal:

Journal of Neuroendocrinology

Year:

2012

Language:

english

File:

PDF, 122 KB

english, 2012

46

Changes in turnover of cerebral monoamines following inhibition of enkephalin metabolism by thiorphan and bestatin

Catherine Llorens-Cortes, Jean-Charles Schwartz

Journal:

European Journal of Pharmacology

Year:

1984

Language:

english

File:

PDF, 388 KB

english, 1984

47

Study of endogenous Tyr-Gly-Gly, a putative enkephalin metabolite, in mouse brain: Validation of a radioimmunoassay, localisation and effects of peptidase inhibitors

Catherine Llorens-Cortes, Claude Gros, Jean-Charles Schwartz

Journal:

European Journal of Pharmacology

Year:

1985

Language:

english

File:

PDF, 677 KB

english, 1985

48

Inhibition of enkephalin degradation by phelorphan: effects on striatal [Met5]enkephalin levels and jump latency in mouse hot plate test

Jan G.C. Van Amsterdam, Catherine Llorens-Cortes

Journal:

European Journal of Pharmacology

Year:

1988

Language:

english

File:

PDF, 457 KB

english, 1988

49

Increase in striatal enkephalin release following stimulation of the D2-dopamine receptor

C. Llorens-Cortes, S. Ledewyn-Zini, J.-C. Schwartz

Journal:

European Journal of Pharmacology

Year:

1990

Language:

english

File:

PDF, 222 KB

english, 1990

50

Detection of the tripeptide Tyr-Gly-Gly, a putative enkephalin metabolite in brain, using a sensitive radioimmunoassay

Catherine Llorens-Cortes, Jean-Charles Schwartz, Claude Gros

Journal:

Year:

1985

Language:

english

File:

PDF, 321 KB

english, 1985

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